DNA2 inhibitor C5 is a potent, competitive, and specific DNA2 nuclease inhibitor with an IC50 of 20 μM. It inhibits the nuclease, DNA-dependent ATPase, helicase, and DNA-binding activities of DNA2. This product can be used in breast cancer and colorectal cancer research. It is for research use only and not sold to patients.
- Potent, competitive, and specific DNA2 nuclease inhibitor
- Inhibits nuclease, DNA-dependent ATPase, helicase, and DNA-binding activities of DNA2
- Useful in breast cancer and colorectal cancer research
- Exhibits strong synergistic effect in inhibiting MCF7 cell survival with MK4827
- Shows synthetic lethality with deficiencies in FEN1, EXO1, or MRE11 genes in mouse model
- IC50 of 20 μM for DNA2 nuclease